为了表明工业化学物经皮肤吸收的可能性,各国均在工业化学物车间空气接触限值(TLV或MAC)的法定名单中,标上“皮肤”这符号,提示职工接触该化学物应注意皮肤防护。但是,近年已有文献指出,不同国家权威机构所制订的安全标准中,标上“皮肤”符号的化学物差异甚大。其主要原因:(1)各国对工业化学物的皮肤吸收缺乏系统研究;(2)采用不同方法得到的皮肤吸收资料无法进行比较;(3)化学物的皮肤吸收率决定于接触和环境条件;(4)工业化学物皮肤吸收的意义缺乏标准。因此,如果没有简单有效的方法去评价化学物的经皮吸收,没有建立皮肤吸收的生物学标准,就不 In order to indicate the possibility of transdermal absorption of industrial chemicals, all countries have the “skin” symbol on the statutory list of industrial chemicals workshop air exposure limits (TLVs or MACs), indicating that workers should be aware of skin when they come into contact with the chemical Protection. However, in recent years, it has been pointed out in the literature that among the safety standards set by the authorities of different countries, the chemicals marked with the “skin” symbol vary greatly. The main reasons are: (1) there is a lack of systematic research on the skin absorption of industrial chemicals in various countries; (2) the skin absorption data obtained by different methods can not be compared; (3) the skin absorption rate of chemicals depends on the contact and environmental conditions; (4) Absorption of industrial chemicals, the significance of the lack of standards. Therefore, if there is no simple and effective way to evaluate the transdermal absorption of chemicals without establishing the biological criteria for skin absorption, then