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目的探讨并分析白细胞介素-6(IL-6)结合降钙素原(PCT)与C-反应蛋白(CRP)在新生儿败血症检测中的临床应用。方法 55例新生儿败血症患儿作为观察组,同期健康新生儿55例为对照组。比较观察组患儿在治疗前与对照组患儿以及观察组患儿在治疗前与恢复期的CRP、PCT和IL-6三项指标的检测结果。结果观察组患儿治疗前的CRP、PCT和IL-6水平均高于对照组,观察组患儿治疗前的CRP、PCT和IL-6水平均高于恢复期,且差异均有统计学意义(P<0.05)。结论 IL-6、PCT和CRP三项联合检测对新生儿败血症的诊断具有重要临床价值。
Objective To investigate and analyze the clinical application of interleukin-6 (IL-6) in combination with procalcitonin (PCT) and C-reactive protein (CRP) in the detection of neonatal sepsis. Methods 55 cases of neonatal sepsis as observation group, 55 healthy newborns over the same period as the control group. The results of three indexes of CRP, PCT and IL-6 before and after treatment in children in observation group and control group were compared before and after treatment. Results Before treatment, the levels of CRP, PCT and IL-6 in the observation group were higher than those in the control group. The levels of CRP, PCT and IL-6 in the observation group before treatment were higher than those in the recovery phase, and the differences were statistically significant (P <0.05). Conclusion The combined detection of IL-6, PCT and CRP has important clinical value in the diagnosis of neonatal sepsis.