乌司他丁(UTI)是作用广泛的酶抑制剂,在急性胰腺炎、心肺转流、围手术期等方面应用较多,效果明确,但在严重烧伤中的临床应用报道尚不多见。UTI是从人尿中提取精制而成的一种分子量为67 000的酸性糖蛋白,它能抑制胰蛋白酶、α糜蛋白酶、巯基酶、纤溶酶等多种蛋白酶,也是一种溶酶体膜稳定剂,能抑制溶酶体酶的释放,最早被应用于临床治疗 Ulinastatin (UTI) is a widely used enzyme inhibitor. It is widely used in acute pancreatitis, cardiopulmonary bypass and perioperative period, and has clear effect. However, the clinical application in the severe burn is still rare. UTI is extracted from human urine purified from a molecular weight of 67 000 acid glycoprotein, it can inhibit trypsin, α chymotrypsin, sulfhydrylase, plasmin and other proteases, but also a lysosomal membrane Stabilizer, can inhibit the release of lysosomal enzymes, the earliest been used in clinical treatment