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本文对35例慢性阻塞性肺疾病(COPD)急性加重期AT-Ⅲ:Ag和FN的关系作出评价。21例AT-Ⅲ:Ag降低(<22.96mg％)。10例FN降低(<185μg/ml),FN降低者其AT-Ⅲ:Ag值均降低。FN降低者和正常者其AT-Ⅲ:Ag分别为12.45±2.86mg％和22.23±4.87mg％(P<0.01)。AT-Ⅲ:Ag和FN值间有一定相互关系(r=0.61 P<0.01)。认为在老年COPD急性加重期,炎症、低氧血症和高碳酸血症促使血栓前状态发生和发展,并形成恶性循环;AT-Ⅲ:Ag可作为早期预测血栓前状态的客观指标。
This article evaluates the relationship between AT-III: Ag and FN in 35 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). 21 cases of AT-III: Ag decreased (<22.96mg%). 10 cases of FN decreased (<185μg / ml), FN decreased their AT-Ⅲ: Ag values were reduced. AT-III: Ag was 12.45 ± 2.86mg% and 22.23 ± 4.87mg%, respectively (P <0.01) in FN decreased and normal subjects. AT-Ⅲ: Ag and FN values have some correlation (r = 0.61 P <0.01). It is believed that inflammation, hypoxemia and hypercapnia promote the occurrence and development of prothrombotic state during the acute exacerbation of COPD and lead to a vicious circle. AT-Ⅲ: Ag may be used as an objective indicator of early prediction of prethrombosis.