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目的观察与分析血清C反应蛋白在急性冠脉综合征中的应用价值,从而为评估病情、指导临床治疗提供依据。方法于2008年1月至2011年6月纳入58例急性冠脉综合征者、22例稳定型心绞痛者和36例健康体检者作为对照,同时对所有研究对象血清C反应蛋白水平进行检测,然后对所得数据进行统计学处理与分析。结果急性冠脉综合征、稳定型心绞痛者血清C反应蛋白水平分别与健康体检者相比差异有统计学意义(P<0.01,P<0.05),而急性冠脉综合征者与稳定型心绞痛相比差异有统计学意义(P<0.05);不稳定型心绞痛者与稳定型心绞痛者相比差异有统计学意义(P<0.05),急性心肌梗死者与稳定型心绞痛者相比差异有统计学意义(P<0.01),而急性心肌梗死者与不稳定型心绞痛相比差异有统计学意义(P<0.05)。结论血清C反应蛋白是急性冠脉综合征发生的独立性危险因素,也是评估病情的重要指标且对判断疾病预后起到了事半功倍的效果。
Objective To observe and analyze the clinical value of serum C-reactive protein in acute coronary syndromes, and to provide the basis for assessing the disease and guiding the clinical treatment. Methods From January 2008 to June 2011, 58 patients with acute coronary syndrome, 22 patients with stable angina pectoris and 36 healthy controls were included in the study. Serum C-reactive protein levels were measured in all subjects at the same time. The data were statistically processed and analyzed. Results The serum levels of C-reactive protein in patients with acute coronary syndrome and stable angina were significantly lower than those in healthy subjects (P <0.01, P <0.05), while those in patients with acute coronary syndrome and stable angina (P <0.05). There was significant difference between unstable angina pectoris and stable angina pectoris (P <0.05). There was significant difference between stable angina pectoris and acute myocardial infarction (P <0.01), while the difference between acute myocardial infarction and unstable angina was statistically significant (P <0.05). Conclusions Serum C-reactive protein is an independent risk factor for acute coronary syndrome and is an important index for assessing the disease and playing a multiplier effect in judging the prognosis of the disease.