目的:探讨整合素α1和嗜铬素A与子宫内膜癌的相关性。方法:收集哈尔滨医科大学附属第四医院病理科2006年5月至2008年10月存档的113例石蜡包埋子宫内膜标本并进行分类,应用免疫组织化学方法检测内膜组织中整合素α1和嗜铬素A的定位及表达情况。结果:在正常子宫内膜、单纯增生、复杂增生、不典型增生及子宫内膜癌中,整合素α1的表达随病变加重呈上升趋势,正常子宫内膜与增生性内膜及内膜癌比较有显著性差异(P<0.05,P<0.001),增生性内膜与内膜癌比较有显著性差异(P<0.05),在内膜癌中,整合素α1表达与细胞分化程度相关;嗜铬素A表达亦呈上升趋势,正常子宫内膜与增生内膜及内膜癌比较有显著性差异(P<0.05,P<0.05),但增生性内膜与内膜癌比较无统计学意义(P>0.05)。结论:整合素α1的过表达与子宫内膜癌的发生相关,嗜铬素A与子宫内膜癌的相关性仍有待于进一步研究。 Objective: To investigate the relationship between integrin α1 and chromogranin A and endometrial carcinoma. Methods: A total of 113 paraffin-embedded endometrium specimens collected from May 2006 to October 2008 in Department of Pathology, the Fourth Affiliated Hospital of Harbin Medical University were collected for classification. Immunohistochemistry was used to detect the expression of integrin α1 and Chromogranin A localization and expression. Results: In normal endometrium, simple hyperplasia, complex hyperplasia, atypical hyperplasia and endometrial carcinoma, the expression of integrin α1 increased with the increase of the lesion. Compared with normal endometrium and proliferative endometrium and endometrial carcinoma There was significant difference (P <0.05, P <0.001), proliferative endometrial and endometrial cancer were significantly different (P <0.05), in endometrial carcinoma, integrin α1 expression and cell differentiation degree; Chromium A expression also showed an upward trend, the normal endometrium and proliferative endometrium and endometrial cancer were significantly different (P <0.05, P <0.05), but proliferative endometrial and endometrial cancer was not statistically significant (P> 0.05). Conclusion: The overexpression of integrin α1 is associated with the occurrence of endometrial cancer. The relationship between chromogranin A and endometrial cancer remains to be further studied.