论文部分内容阅读
炎症性肠病包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn’s disease,CD),为反复发作的肠道炎性疾病。其发病机制十分复杂,主要集中于感染因子的作用、遗传易感性的影响和免疫调节异常等。肠道感染特别是反复持续感染使细菌及其产物启动肠道炎症破坏黏膜屏障,使固有膜黏膜相关淋巴组织暴露,并激活肠道巨噬细胞、淋巴细胞,通过特异的免疫调节途径释放多种细胞因子,产生一系列炎症反应,甚至使之放大与慢性化,而遗传易感性使免疫调节异常,决定了辅助T细胞(Th细胞)激活占优势的免疫反应,产生各种细胞因子及炎症介质,引起和放大黏膜的炎症。治疗时应根据疾病的部位与范围、活动性与严重程度、病人的全身情况及并发症选择治疗方案。Sands根据
Inflammatory bowel disease includes ulcerative colitis (UC) and Crohn’s disease (CD), a recurrent inflammatory bowel disease. The pathogenesis is very complex, mainly focused on the role of infectious agents, genetic susceptibility and immunomodulatory disorders. Intestinal infections, especially repeated infections continue to make bacteria and their products start intestinal inflammation damage mucosal barrier, the inherent membrane mucosa-associated lymphoid tissue exposure, and activate intestinal macrophages, lymphocytes, release a variety of specific immunomodulatory pathways Cytokines, a series of inflammatory reactions, and even make it amplified and chronic, and genetic predisposition to abnormal immune regulation, the decision of the helper T cells (Th cells) to activate the immune response, the production of a variety of cytokines and inflammatory mediators , Causing and amplifying mucosal inflammation. Treatment should be based on the location and extent of the disease, activity and severity, the patient’s general condition and complications of treatment options. According to Sands