目的　了解燃煤型砷中毒皮肤角化点继发皮肤癌变的情况。方法　采用流行病学调查及必要的临床体症结合有关回顾性调查资料进行。结果　通过 15例砷中毒患者的追踪观察得出 :砷中毒病人皮肤角化到癌变的间变期初步认为在 15年以上 ,平均为 17.5年 ,角化部位的外伤不易愈合 ,且易发生感染 ,是加速癌变的诱因 ,并分析了手、足皮肤角化点癌变发生率高的各种因素。结论　砷中毒病区的中毒患者 ,角化部位出现经久不愈的溃疡应首先考虑癌变的可能 Objective To understand the situation of carcinogenesis of secondary cutaneous skin in coal-fired arsenic poisoned skin. Methods Epidemiological surveys and clinical signs with the relevant retrospective survey data. Results A follow-up observation of 15 cases of arsenic poisoning patients showed that: arsenic poisoning patients skin keratosis to carcinogenesis of the interim period initially considered more than 15 years, an average of 17.5 years, keratosis trauma is not easy to heal, and prone to infection, Is to accelerate the cause of cancer, and analysis of the hand, foot skin keratosis point of high incidence of various factors. Conclusion Arsenic poisoning wards poisoning patients, keratosis ulcers should first consider the possibility of cancer