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目的通过对3月~3岁幼儿血清25羟-维生素D3正常参考水平调查,了解湖南地区幼儿维生素D营养状况,为临床诊断维生素D缺乏性佝偻病提供实验室依据。方法以湖南地区2008年5月-2009年4月来儿童保健科体检的3月~3岁健康幼儿1 110人为研究对象,取血查其血清25羟-维生素D3水平。结果湖南地区3月~3岁幼儿血清25-(OH)D3平均水平为(84.37±29.26)nmol/L,健康男童血清25羟-维生素D3水平与女童组比较差异无统计学意义;男、女童夏秋季25羟-维生素D3水平明显高于冬春季;3月~1岁幼儿25羟-维生素D3水平明显低于1~3岁幼儿。结论湖南地区幼儿维生素D营养状况处于较好水平,健康幼儿不同年龄、不同季节的血清25羟-维生素D3正常参考值水平有一定差异。
Objective To investigate the normal reference level of 25-hydroxyvitamin D3 in preschool children aged 3 months to 3 years to understand the nutritional status of children’s vitamin D in Hunan and to provide a laboratory basis for the clinical diagnosis of vitamin D-deficiency rickets. Methods A total of 1 110 healthy children aged 3 months to 3 years from the Department of Child Health Care Check-up in Hunan Province from May 2008 to April 2009 were selected as study subjects. Blood was taken for serum 25-hydroxyvitamin D3 level. Results The mean level of 25- (OH) D3 in children aged 3 months to 3 years old in Hunan was (84.37 ± 29.26) nmol / L, while the level of 25-hydroxyvitamin D3 in healthy boys was no significant difference compared with that of girls. The levels of 25-hydroxy-vitamin D3 in summer and autumn were significantly higher than those in winter and spring. The levels of 25-hydroxyvitamin D3 in children aged 3 months to 1 year were significantly lower than those in children 1-3 years old. Conclusion The nutritional status of vitamin D in young children in Hunan is at a good level. There are some differences in the normal reference values of serum 25-hydroxyvitamin D3 in different ages and ages of healthy children.