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目的:全面收集并分析国内外公开发表的处方序列对称分析(PSSA)相关文献,为我国今后同类研究的设计提供参考。方法:系统检索Pub Med和Embase文献数据库中的PSSA文献,检索时间截止到2015年11月5日。用Epidata软件建立数据提取表,使用SPSS软件进行统计分析。结果:共检索文献并纳入研究53篇。自2012年后,文献发表数量快速提高。发表文献作者主要集中在澳大利亚、荷兰、日本等国家。大部分研究使用数据库为医疗保险理赔数据库。结论:近年来国际上关于PSSA研究不断增加,应用也不断成熟。虽然PSSA仍需要方法学的不断考证,但为大数据在药物安全性研究中的应用提供了新的思路。
OBJECTIVE: To comprehensively collect and analyze the published literature about PSSA at home and abroad, and provide references for the design of similar researches in our country in the future. Methods: The PSSA data of Pub Med and Embase database were searched systematically. The search time was up to November 5, 2015. Epidata software to establish data extraction table, the use of SPSS software for statistical analysis. Results: A total of 53 articles were retrieved and included in the study. Since 2012, the number of published papers has increased rapidly. The authors of the published literature are mainly concentrated in Australia, the Netherlands, Japan and other countries. Most studies use the database as a medical insurance claims database. Conclusion: In recent years, there has been an increasing number of studies on PSSA in the world and their applications are also mature. Although PSSA still needs constant research on methodology, it provides a new idea for the application of big data in drug safety research.