论文部分内容阅读
方法：对４０例难治性癫痫（１．Ｅ．），根据原用抗癫痫药（ＡＥＤｓ）的不同分为三组，开放性观察３～２８（１２．７±７．８）月。比较拉莫三嗪（ＬＴＧ）与不同ＡＥＤｓ配伍的效果，与安全性及ＬＴＧ常用维持剂量。有两个亚组（共１７例）均用过两种治疗方案，将这两个亚组加用ＬＴＧ的不同配伍用药法进行上述统计学比较。结果：ＬＴＧ与丙戊酸盐（ＶＰＡ）配合获得较好效果，且ＬＴＧ用量少，副作用并不比其它ＡＥＤｓ多，对部分性与继发全面性发作均有较好效果，尤其是对Ｌｅｎｎｏｘ－Ｇａｓ－ｔａｕｔ综合征有较满意的疗效。结论：ＬＴＧ系广谱ＡＥＤ，在ＩＥ的治疗中，与ＶＰＡ配伍系较满意的选择之一。
Methods: Forty patients with intractable epilepsy (1.E.) were divided into three groups according to the different antiepileptic drugs (AEDs). The open observation ranged from 3 to 28 (12.7 ± 7.8) months. Compare the effect of lamotrigine (LTG) with different AEDs compatibility, and safety and LTG commonly used maintenance dose. There are two subgroups (17 cases in total) have used two treatment options, these two subgroups plus LTG different compatibility medication method for the above statistical comparison. Results: LTG and VPA obtained good results, and LTG with less dosage, side effects and no more than other AEDs, partial and secondary comprehensive attack have better results, especially for Lennox- Gas-taut syndrome has a more satisfactory effect. CONCLUSION: LTG is one of the more satisfactory options for the compatibility of broad-spectrum AED with VPA in the treatment of IE.