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虽然外周血造干细胞自体移植(HSCT)在成人造血干细胞移植中广泛应用,但在儿童白血病(AL)中较少有动员外周血造血干细胞进行自体移植的经验。本文根据大量儿童AL患者的动员结果,对DIAVE动员方案的有效性进行评估。 方法 1995年1月～2001年6月,共29(男20、女9)例儿童AL患者进行了外周血动员HSCT以拯救大剂量化疗;中位年龄8(3～21)岁,中位体重34(15～73)kg;23例为急性淋巴细胞白血病(ALL),分别处于第2缓解期(CR2,21例)及CR3(2例);6例为急性非淋巴细胞白血病(ANLL),处于CRI。在诱导及巩固化疗结束后,采用DIAVE方案动员,包括:地塞米松5mg/m_2每日1次,共7日;去甲氧柔红霉素10mg/m_2和阿糖胞苷3mg/m_2第1日;长
Although peripheral blood stem cell autologous transplantation (HSCT) has been widely used in adult hematopoietic stem cell transplantation, there is less experience of autologous transplantation of peripheral blood stem cells in childhood leukemia (AL). This article evaluates the effectiveness of DIAVE mobilization programs based on the mobilization results of a large number of children with AL. Methods From January 1995 to June 2001, a total of 29 male (20 males and 9 female) AL patients underwent peripheral blood mobilization HSCT to rescue high-dose chemotherapy. The median age was 8 (range 3-21) years. The median body weight 34 cases (15-73 kg); 23 cases were acute lymphoblastic leukemia (ALL), respectively in the second remission (CR2,21 cases) and CR3 (2 cases); 6 cases were acute non-lymphocytic leukemia (ANLL) At CRI. After induction and consolidation of chemotherapy, the DIAVE regimen was used to mobilize, including dexamethasone 5 mg / m 2 once daily for 7 days, daunorubicin 10 mg / m 2 and cytarabine 3 mg / m 2 for 1 Day