库欣综合征(CS)中15%～20%是由肾上腺原因引起的,其中约10%的患者具有双侧肾上腺增生。肾上腺性CS中皮质醇分泌有时可受肾上腺异常膜受体(包括抑胃肽受体、精氨酸加压素受体、儿茶酚胺类受体、LH/hCG受体和5-羟色胺受体等)的调节。该文报道了1例促肾上腺皮质激素非依赖性大结节样肾上腺增生引起的CS患者,并通过体内试验证实了肾上腺异常膜受体的存在。 15% to 20% of Cushing’s syndrome (CS) is caused by adrenal causes, with about 10% of patients having bilateral adrenal hyperplasia. Adrenal CS Cortisol secretion can sometimes be affected by adrenal abnormal membrane receptors (including gastric inhibitory peptide receptors, arginine vasopressin receptors, catecholamine receptors, LH / hCG receptors and serotonin receptors, etc.) Adjustment. This paper reports a case of adrenal cortical hormone-independent large nodular adrenal hyperplasia-induced CS patients and confirmed the presence of adrenal abnormal membrane receptors by in vivo experiments.