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目的观察脑脊液(CSF)中的胱抑素C(Cys-C)水平用于诊断新生儿窒息后脑损伤的价值。方法选择50例窒息新生儿作为研究对象,轻度窒息的26例为Ⅰ组,重度窒息的24例为Ⅱ组,另选择行CSF检查未有窒息症状的22例新生儿为Ⅲ组,对三组新生儿的Cys-C水平与预后效果加以比较。结果Ⅲ组新生儿CSF中的Cys-C水平及出生12~14 d后新生儿神经行为测定(NBNA)评分明显地高于Ⅰ组以及Ⅱ组,差异有统计学意义(P<0.05),且Ⅰ组均明显高于Ⅱ组,差异有统计学意义(P<0.05)。结论新生儿窒息程度越高,脑脊液中的胱抑素水平越低,脑损伤的程度越严重,预后效果越差。因此,脑脊液中Cys-C水平具有重要的诊断价值。
Objective To investigate the value of cystatin C (Cys-C) in cerebrospinal fluid (CSF) for the diagnosis of brain injury after neonatal asphyxia. Methods Fifty neonates with asphyxia were selected as study object. Twenty-six patients with mild asphyxia were Group I and 24 patients with severe asphyxia were Group II. Another 22 neonates with no asphyxia were selected as Group III, Cys-C levels in newborns were compared with the prognosis. Results The level of Cys-C in neonate CSF and the neonate neurobehavioral score (NBNA) at 12-14 days after birth in group Ⅲ were significantly higher than those in group Ⅰ and Ⅱ (P <0.05) Ⅰ group were significantly higher than the Ⅱ group, the difference was statistically significant (P <0.05). Conclusion The higher the degree of neonatal asphyxia, the lower the level of cystatin in cerebrospinal fluid and the more serious the degree of brain injury, the worse the prognosis. Therefore, the level of Cys-C in cerebrospinal fluid has important diagnostic value.