肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）是近年来研究较深入、应用较广泛的一种细胞因子。大部分实验和临床研究都侧重于探索其免疫系统的作用。近几年不少实验证明其与中枢神经系统也有着密切的联系。ＴＮＦ可影响体温调节、自主活动、摄食、睡眠、神经内分泌、镇痛、中枢内感染等。外周ＴＮＦ可进入中枢，中枢自身也可产生ＴＮＦ。 Tumor necrosis factor (TNF) is a more in-depth study in recent years, more widely used as a cytokine. Most experimental and clinical studies have focused on exploring the role of the immune system. In recent years, a lot of experiments prove that it has a close connection with the central nervous system. TNF can affect body temperature regulation, autonomic activity, feeding, sleep, neuroendocrine, analgesic, central infection and so on. Peripheral TNF can enter the central nervous center itself can produce TNF.