1880年Eberth自伤寒患者尸体的脾脏和肠系膜淋巴结內发现伤寒杆菌。1884年Gaffky分离成功。1898年Mallory提出伤寒杆菌能产生一种毒性物质的论点。自此以后,许多学者对伤寒的发病机制,进行了各方面的研究,其中对于伤寒杆菌的致病因素研究得较多。虽然多年来积累了许多资料,但要用于全面解释伤寒的发病机制还很不够。本文将目前有关伤 In 1880 Eberth found typhoid bacillus in the spleen and mesenteric lymph nodes of typhoid fever patients. 1884 Gaffky separation success. In 1898 Mallory made the argument that Salmonella typhi produced a toxic substance. Since then, many scholars have carried out various aspects of the pathogenesis of typhoid fever, of which more are studied for the pathogenic factors of typhoid bacillus. Although many data have been accumulated over the years, it is still not enough to explain the pathogenesis of typhoid fever comprehensively. This article will be about the current injury