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目的对比基础—餐时胰岛素与胰岛素泵在T2DM治疗中的有效性和安全性。方法将68例T2DM患者随机分为两组,A组采用三餐前门冬胰岛素联合睡前地特胰岛素治疗,B组采用胰岛素泵(使用门冬胰岛素)降糖治疗。治疗3个月后对比两组血糖控制情况、血糖达标所需要的时间、胰岛素用量、低血糖发生率等情况。结果两组治疗后HbA1c、FPG、2hPG均较治疗前显著下降(P<0.01),而FC-P、2hC-P均较治疗前明显升高(P<0.01)。上述指标两组之间无统计学差异(P>0.05)。两组血糖达标时间、日治疗剂量及低血糖发生率均无统计学差异(P>0.05),但A组的日治疗费用明显低于B组(P<0.05)。结论地特胰岛素联合三餐前门冬胰岛素强化治疗能有效模拟人生理胰岛素分泌,有效控制高血糖,且效价比优于胰岛素泵强化治疗。
The purpose of comparison basis - meal insulin and insulin pump in the treatment of T2DM effectiveness and safety. Methods Sixty-eight patients with T2DM were randomly divided into two groups. Group A was treated with insulin aspart aspart and insulin before going to bed in group A, and insulin pump (with insulin aspart) in group B. After 3 months of treatment, the two groups were compared with the control of blood glucose, the time needed to reach the blood glucose level, the dosage of insulin and the incidence of hypoglycemia. Results The levels of HbA1c, FPG and 2hPG in both groups were significantly lower than those before treatment (P <0.01), while the levels of FC-P and 2hC-P in both groups were significantly higher than those before treatment (P <0.01). There was no significant difference between the above two groups (P> 0.05). There was no significant difference between the two groups (P> 0.05), but the daily cost of treatment in group A was significantly lower than that in group B (P <0.05). CONCLUSION: Combination of insulin detemir and triple-meal insulin aspart before intensive insulin treatment can effectively simulate physiological insulin secretion and effectively control hyperglycemia with better potency than insulin pump.