本文基于知识生产函数在创新系统方法下的扩展框架,构建了中国区域创新系统功能有效性诊断的路径框架、指标体系及检验模型.在检验模型中,本文引入了偏最小二乘(PLS)回归模型和PLS路径分析模型,以获得稳健而有效的检验结果.本文构建的“功能-结构-检验”综合框架为创新系统方法从理论探索走向实证研究提供了可行且有效的途径.基于面板数据,本文在全面分析比较中国区域创新系统创新产出决定因素的重要性差异的基础上,进一步验证和表明中国区域创新系统功能框架基本形成,但还不完善.“,”This study has built a diagnostic path and measurement framework for the functional effectiveness of China's regional innovation systems, which is based on the extended framework of knowledge production function in the context of innovation systems approach. This study employed a PLS - based diagnostic mod- el for obtaining robust and effective test results. Our diagnostic framework provides an feasible and effective way for innovation systems approach from theoretical in- vestigations to empirical applications. By a panel - data - based empirical study this paper compared the importance of determinants of China's regional scientific and technological outputs. Our empirical test results show that the functional frame- work of China's regional innovation systems has formed, but it is not perfect.