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目的 :研究六味地黄汤及其配伍对血小板聚集率的影响。方法 :本实验采用体外血小板聚集法 ,利用不同的诱导剂 ,观察了六味地黄汤及其拆方对血小板聚集率的抑制作用。结果 :六味地黄汤全方和三补、三泻方均能抑制腺嘌呤核苷二磷酸 (ADP)诱导的体外血小板聚集 ,对花生四烯酸 (AA)诱导的血小板聚集也有抑制作用 ,但用药剂量较大 ,其中以全方药效最强 ,三补方次之 ,三泻方最弱 ,药物血清也呈现相似的结果。结论 :六味地黄汤具有良好的抑制血小板聚集的作用 ,三味补药是其作用的主要成分 ,三补与三泻配伍具有协同和增效作用。
Objective: To study the effect of Liuwei Dihuang Decoction and its compatibility on the platelet aggregation rate. Methods: In this study, in vitro platelet aggregation was used. Using different inducers, the inhibitory effect of Liuwei Dihuang Decoction and its disassembled prescription on platelet aggregation was observed. RESULTS: All of Liuwei Dihuang Decoction, Sanbu and Sanxi prescriptions could inhibit platelet aggregation induced by adenosine diphosphate (ADP) in vitro, and inhibit platelet aggregation induced by arachidonic acid (AA), but they were used as drugs. The dose is relatively large, of which the full effect is strong, the third is the second, and the third is the weakest. The drug serum also shows similar results. Conclusion : Liuwei Dihuang Decoction has a good effect of inhibiting platelet aggregation. Sanwei tonic is the main component of its action. Sanbu and Sanxia have a synergistic and synergistic effect.