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目的探讨内皮特异性分子1(ESM-1)对子宫内膜癌发生、发展的影响及其与血管生成的关系。方法随机选取2015年1-12月该院妇科经手术治疗的子宫内膜腺癌石蜡标本26例为子宫内膜腺癌组,以同期20例子宫内膜不典型增生组织为癌前病变组,并以20例正常增生期子宫内膜组织为对照组。采用免疫组织化学方法及图像分析技术检测ESM-1及CD105标记的微血管密度(MVD)在子宫内膜腺癌、子宫内膜不典型增生及正常增生期子宫内膜的表达。结果 ESM-1及CD105-MVD在正常增生期子宫内膜、子宫内膜不典型增生及子宫内膜腺癌中的表达依次升高,差异有统计学意义(P<0.05)。子宫内膜腺癌中ESM-1与MVD的表达之间呈正相关(r=0.776,P<0.001)。结论 ESM-1的过量表达与子宫内膜腺癌血管生成密切相关,提示ESM-1参与了子宫内膜腺癌的发生、发展及血管生成的过程。
Objective To investigate the effect of endothelial-specific molecule 1 (ESM-1) on the occurrence and development of endometrial carcinoma and its relationship with angiogenesis. Methods Totally 26 cases of endometrial adenocarcinoma paraffin embedded in gynecology department of our hospital from January to December in 2015 were selected as endometrial adenocarcinoma group, 20 cases of endometrial dysplasia group as precancerous lesion group, 20 cases of normal proliferative endometrium as control group. The expression of ESM-1 and CD105-labeled microvessel density (MVD) in endometrial adenocarcinoma, endometrial dysplasia and normal proliferative endometrium were detected by immunohistochemistry and image analysis. Results The expression of ESM-1 and CD105-MVD in normal proliferative endometrium, endometrial dysplasia and endometrial adenocarcinoma increased in turn, with statistical significance (P <0.05). There was a positive correlation between the expression of ESM-1 and MVD in endometrial adenocarcinoma (r = 0.776, P <0.001). Conclusion The overexpression of ESM-1 is closely related to angiogenesis in endometrial adenocarcinoma, suggesting that ESM-1 is involved in the pathogenesis, development and angiogenesis of endometrial adenocarcinoma.