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肺癌分为非小细胞肺癌(NSCLC)和小细胞肺癌(SCLC)两大类,其中NSCLC约占80%以上。目前肺癌总的5年生存率只有15%左右,90%以上患者死于肺瘤侵袭和转移的相关并发症。侵袭和转移是恶性肿瘤的两个最主要的生物学特征和标志,近年来研究发现了与肿瘤转移呈正负相关的肿瘤转移相关基因和肿瘤转移抑制相关基因,前者的激活和(或)后者的失活能促进或导致肿瘤转移的发生。
Lung cancer is divided into two categories of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), of which about 80% of NSCLC. The overall 5-year survival rate of lung cancer is only about 15%, 90% of patients died of lung cancer invasion and metastasis-related complications. Invasion and metastasis are the two most important biological characteristics and signs of malignant tumors. In recent years, studies have found that the metastasis-related genes and tumor metastasis-related genes that are positively and negatively correlated with tumor metastasis, the activation and / or after Inactivation can promote or lead to the occurrence of tumor metastasis.