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前列腺素(Prostaglandins,简称PG)是一组几乎存在于哺乳动物各重要组织和体液中的生物活性物质。各种PG对不同功能状态下的不同组织作用各异。其中对子宫肌、血管和血小板的作用概括如下:(1)子宫收缩:TXA_2、PGE_2和PGF_(2α)促进子宫肌收缩,排卵期子宫对PGE敏感,妊娠期子宫对PGF敏感。PGI_(?)抑制子宫收缩。(2)血管舒缩:TXA_2,PGF_(2α)、PGG_2和PGH_2收缩血管、PGI_2、PGE_2舒张血管。(3)血小板聚集:TXA_2、PGG_1、PGH_2促聚血小板;PGI_2、PGE_1抑制血小板聚集。
Prostaglandins (PGs) are a group of biologically active substances found in almost all important mammalian tissues and body fluids. Various PGs have different effects on different tissues under different functional states. Among them, the effects on uterine muscle, blood vessels and platelets are summarized as follows: (1) Uterine contraction: TXA_2, PGE_2 and PGF_ (2α) promote contraction of uterine muscle; ovulation uterus is sensitive to PGE; pregnant uterus is sensitive to PGF. PGI_ (?) Inhibits uterine contractions. (2) vasomotor: TXA_2, PGF_ (2α), PGG_2 and PGH_2 constrict blood vessels, PGI_2, PGE_2 vasodilators. (3) Platelet aggregation: TXA_2, PGG_1, PGH_2 promote platelet aggregation; PGI_2, PGE_1 inhibit platelet aggregation.