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目的 探讨原发性肝癌血清一氧化氮 (NO)含量变化及其临床意义。方法 检测 2 1例中晚期原发性肝癌患者及 36例健康对照者血清亚硝酸盐水平间接反应血清NO的含量 ,前者与所测量瘤体最大径进行相关分析。结果 原发性肝癌患者血清NO(12 .34± 3 .0 6 μmol/L)明显高于健康对照组 (9.6 6± 1.5 2 μmol/L) (P <0 .0 1)。原发性肝癌患者血清NO与肿瘤直径呈正相关关系 (r =0 .5 132 ,P =0 .0 174)。结论 NO在原发性肝癌的发生发展中起重要作用 ,肝癌患者血清NO水平测定对肝癌诊断、治疗及预后的评价具有一定的意义。
Objective To investigate the changes of serum nitric oxide (NO) in primary hepatocellular carcinoma and its clinical significance. Methods Serum nitrite level was detected in 21 patients with primary hepatocellular carcinoma (HCC) and 36 healthy controls. The former was correlated with the largest diameter of the tumor. Results Serum NO (12.34 ± 3.06 μmol / L) in patients with primary liver cancer was significantly higher than that in healthy controls (9.6 6 ± 1.5 2 μmol / L) (P <0.01). There was a positive correlation between serum NO and tumor diameter in patients with primary liver cancer (r = 0.5132, P = 0.0174). Conclusion NO plays an important role in the occurrence and development of primary liver cancer. Determination of serum NO in patients with liver cancer has certain significance for the diagnosis, treatment and prognosis of liver cancer.