目的:评估经结膜注射A型肉毒毒素治疗甲状腺相关眼病上睑退缩的临床效果。方法:回顾性研究。对山西省眼科医院2017年7月至2018年7月13例(17眼)甲状腺相关眼病上睑退缩行经结膜睑板上缘A型肉毒毒素(2.5~10 IU)注射，根据患者上睑下垂的程度不同，注射不同剂量的药物。随访观察3天~12周。结果:在注射后2~3天94%(16/17)病例出现麻痹效果，注射后2周达高峰，12周药物失去作用，需要重复注射。9眼上睑退缩改善0~1.0 mm，5眼改善1.5~2.0 mm，2眼改善2.0~3.0 mm，1眼无明显改善。无上睑退缩加重者。暂时性的上睑下垂1眼。暂时性眼睑闭合不全2眼。结论:结膜下注射A型肉毒毒素是一种有效的治疗甲状腺相关眼病上睑退缩的方法。“,”Objective:To evaluate the clinical efficacy of subconjunctival injection of botulinum toxin type A for treating upper eyelid retraction related to thyroid-associated ophthalmopathy.Methods:This was a retrospective case study. A total of 17 eyes of 13 patients with upper eyelid retraction related to thyroid-associated ophthalmopathy from Jul. 2017 to Jul. 2018 in Shanxi Eye Hospital received botulinum toxin type A injection (2.5-10 IU). Based on the degree of ptosis, different doses of drugs were injected. The followed-up time were 3 days-12 weeks.Results:The paralysis occurred in 94% (10/17) of the cases at 2-3 days after injection, and reached peak at 2 weeks after injection. The drug was ineffective at 12 weeks after injecton and repeated injection was required. The upper eyelid retraction was improved within 0-1.0 mm in 9 eyes, 1.5-2.0 mm in 5 eyes, 2.0-3.0 mm in 2 eyes, none-significant improvement in 1 eye. There was no aggravation of upper eyelid retraction. One patient developed a temporary ptosis with a duration of 2 weeks after injection, and the ptosis gradually recovered after 2 weeks. Two eyes had temporary lagophthalmus.Conclusion:The subconjunctival injection of botulinum toxin type A is effective for upper eyelid retraction associated with thyroid-associated ophthalmopathy.