神经皮肤综合征是小儿神经疾患中一类较少见疾病.此类疾病主要表现为起源于外胚层的组织、器官(如神经、皮肤和眼睛等)异常,临床症状多样化,往往被误诊。现将我们诊治的16例病人总结报道如下:一、一般资料性别:男12例,女4例。就诊年龄:1岁以内5例,～7岁8例,～12岁3例。19例病人中结节性硬化9例,脑三叉神经血管瘤4例.神经纤维瘤病2例,Refusm’s Neurodermatosis is a rare disease in children with neurological disorders, which are mainly manifested as abnormalities of tissues and organs (such as nerves, skin and eyes) originating from ectoderm and diversified clinical symptoms, which are often misdiagnosed. Now we diagnosed 16 patients summarized as follows: First, the general information of gender: 12 males and 4 females. Treatment age: 5 cases were less than 1 year old, 8 cases were ~ 7 years old and 3 cases were ~ 12 years old. Nineteen patients had tuberous sclerosis and four had trigeminal hemangioma in 19 patients, two patients had neurofibromatosis, Refusm’s