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目的:目的:探讨老年失眠症患者艾司唑仑治疗前后睡眠脑电(Quisi)及失匹性负波变化。方法:对64例老年失眠症患者连续进行4夜Quisi描记,其中第3、4晚上睡前予2mg艾司唑仑,观察用药后Quisi的变化。正常老人组56名,做2夜适应和基础Quisi监测。结果:(1)老年失眠症患者服用艾司唑仑后夜间Quisi显示睡眠效率提高(基线睡眠值87.5%±8.1%,第3晚服药后91.2%±7.9%,第4晚服药后91.9%±3.2%,F值5.94,P<0.05),觉醒时间减少(同前,37.9±16.1分,28.4±7.5分,24.3±6.5分,F值7.21,P<0.01),S1减少(同前,30.9±18.2%,24.1±11.0%,16.2±6.2%,F值8.90,P<0.01),S2增加(同前,43.0±16.3%,59.1±17.2%,59.1±5.7%,F值7.61,P<0.01),睡眠潜伏期缩短(同前,34.6±18.9分,26.9±16.5分,20.4±10.9分,F值3.95,P<0.05)。(2)与正常老人组相比,老年失眠症患者在MMN潜伏期延迟,波幅下降(P<0.01)。与此同时,P300也见同一趋势变化(P<0.05或0.01)。结论:(1)艾司唑仑不仅能改善老年患者对睡眠的主观评价,还对夜间睡眠脑电有影响。(2)我们的临床经验并建议,对普通及老年失眠症患者治疗首选艾司唑仑。
Objective: To investigate the changes of sleep-induced electroencephalogram (Quisi) and the negative cascade of prediabetes in elderly patients with insomnia before and after estazolam treatment. Methods: Sixty-four elderly patients with insomnia were subjected to 4-night Quisi tracing. The third and fourth night were given 2 mg estazolam before going to bed at night, and the changes of Quisi after administration were observed. The normal elderly group 56, 2 nights to adapt and basic Quisi monitoring. Results: (1) Quisi at night after admission of estazolam in elderly patients with insomnia showed an increase in sleep efficiency (baseline sleep 87.5% ± 8.1%, 91.2% ± 7.9% after 3 days, 91.9% ± after 4 days (F = 7.21, P <0.01), S1 decreased (same as before, 30.9%, P <0.05), and the time of awakening decreased (same as before, 37.9 ± 16.1, 28.4 ± 7.5, 24.3 ± 6.5, (P <0.01), and the increase of S2 was the same as before (43.0 ± 16.3%, 59.1 ± 17.2%, 59.1 ± 5.7%, F = 7.61, P < 0.01), shortened sleep latency (same as before, 34.6 ± 18.9, 26.9 ± 16.5, 20.4 ± 10.9, F = 3.95, P <0.05). (2) Compared with the normal control group, the latency of MMN in elderly patients with insomnia was delayed and the amplitude was decreased (P <0.01). In the meantime, P300 also saw the same trend change (P <0.05 or 0.01). Conclusion: (1) Estazolam can not only improve the subjective evaluation of sleep in elderly patients, but also affect the nighttime sleep EEG. (2) Our clinical experience and recommendations for the treatment of patients with insomnia and general elderly preferred eszolam.