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用超临界流体快速溶胀技术和超临界流体辅助雾化技术耦合法制得胰岛素-三棕榈酸甘油酯复合微粒。考察了操作温度和胰岛素溶液流量对复合微粒的形貌和粒径的影响。结果表明,45℃下得到的复合微粒平均粒径为25μm,50℃下(不同胰岛素溶液流量)得到的复合微粒平均粒径为3.9μm。体外释放试验表明,50℃时得到的复合微粒具有较好的缓释效果,120 min时累积释放率为36%,释放完全约需112.5 h。
The insulin-tripalmitin composite particles were prepared by the supercritical fluid rapid swelling technique and the supercritical fluid assisted atomization technique. The effects of operating temperature and insulin solution flow rate on the morphology and particle size of the composite particles were investigated. The results showed that the average diameter of the composite particles obtained at 45 ℃ was 25μm, and the average diameter of the composite particles obtained at 50 ℃ (different insulin solution flow rate) was 3.9μm. The in vitro release test showed that the composite particles obtained at 50 ℃ had a better sustained-release effect, with a cumulative release rate of 36% at 120 min and a complete release of about 112.5 h.