论文部分内容阅读
目的比较不同HbA_1c水平T2DM患者胰岛功能状态。方法随机搜集2015年1月至2016年8月于武汉大学中南医院的T2DM患者208例,按HbA_1c水平分为HbA_1c≤7.0%组、7.0%10.7%组。比较各组FPG、1hPG、2hPG,FIns及0.5hIns、1hIns、2hIns、3hIns水平,以及胰岛素曲线下面积(AUC_(Ins))、校正后的胰岛素分泌指数(MBCI)、胰岛素分泌指数(HOMA-IS)、胰岛素抵抗指数(HOMA-IR)、胰岛素倍增指数(Δ0.5hIns、Δ1hIns、Δ2hIns、Δ3hIns)的变化趋势及差异。结果随着HbA_1c水平升高,血糖、胰岛素(FIns除外)、HOMA-IS、AUC_(Ins)、胰岛素倍增指数均逐渐下降,HOMA-IR早期逐渐升高,晚期下降,MBCI与HbA_1c无相关性。结论 HbA_1c对胰岛素分泌有影响,但对FIns仅在后期(HbA_1c>10.7%)有影响,对HOMA-IR的影响尚不明确,对MBCI无影响。
Objective To compare the functional status of islets in T2DM patients with different HbA1c levels. Methods Totally 208 T2DM patients from Zhongnan Hospital of Wuhan University from January 2015 to August 2016 were randomly divided into HbA_1c≤7.0% group, 7.0% HbA_1c≤8.8% group and 8.8% HbA_1c≤10.7% Group and HbA_1c> 10.7% group. The levels of FPG, 1hPG, 2hPG, FIns and 0.5hIns, 1hIns, 2hIns and 3hIns in each group were compared, and the area under the curve of insulin (AUC_Ins), MBCI, HOMA- ), Insulin resistance index (HOMA-IR) and insulin multiplication index (Δ0.5hIns, Δ1hIns, Δ2hIns, Δ3hIns). Results With the increase of HbA_1c levels, blood glucose, insulin (except FIns), HOMA-IS, AUC (Ins) and insulin multiplication index gradually decreased. HOMA-IR increased at early stage and decreased at later stage. MBCI had no correlation with HbA_1c. Conclusion HbA_1c has an effect on insulin secretion, but has no effect on FIns only in late stage (HbA_1c> 10.7%). The effect of HbA_1c on HOMA-IR is not clear and has no effect on MBCI.