论文部分内容阅读
目的:分析并发神经精神性狼疮(NPSLE)的儿童狼疮性肾炎(LN)患者的临床特点。方法:对122例首次诊断为NPSLE合并LN的住院患者进行回顾性研究,收集其临床资料,比较儿童起病组(n=34)与成年起病组(n=88)的临床特点,包括:性别、系统性红斑狼疮(SLE)的病程、临床表现、实验室检查等。结果:儿童起病组SLE病程较成年起病组短(P<0.05);儿童起病组NPSLE以痫性发作为主(70.6%),而成年起病组以精神症状为主(52.3%),两组间存在显著性差异。成年起病组发生白细胞减少的比例明显高于儿童起病组(P<0.05)。结论:儿童起病的NPSLE合并LN患者的SLE病程、NPSLE临床类型、发生白细胞减少的比例与成年起病者不同,对不同年龄起病的NPSLE合并LN患者应给予不同的治疗策略。
Objective: To analyze the clinical features of children with lupus nephritis (LN) complicated with neuropathic lupus (NPSLE). Methods: A retrospective study was performed on 122 hospitalized patients with NPSLE complicated with LN. Clinical data were collected and compared between children with onset of disease (n = 34) and adults with onset of disease (n = 88), including: Gender, the course of systemic lupus erythematosus (SLE), clinical manifestations, laboratory tests and the like. Results: The onset of SLE in children onset group was shorter than that in adult onset group (P <0.05). The onset of NPSLE in children was mainly seizure (70.6%), while the incidence of psychosis was mainly in adult onset group (52.3% There were significant differences between the two groups. The incidence of leukopenia in adult onset group was significantly higher than that in childhood onset group (P <0.05). CONCLUSIONS: The incidence of SLE, the clinical type of NPSLE, and the incidence of leukopenia in children with NPSLE complicated with LN are different from those in adult patients. Different treatment strategies should be given to patients with NPSLE complicated with LN at different ages.