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目的:观察钙通道阻滞药硫氮唑酮(Dil)长期应用对肾移植受者环孢素A(CsA)用量和肾功能的影响。方法:将Dil用于67例服用CsA的肾移植受者,以同期59例肾移植受者为对照,调整2组CsA血药浓度在治疗窗范围内,观察2组用药后36mo内CsA用量以及血肌酐变化。结果:术后第12、24、36moDil组每例CsA用量较对照组同期平均少14353、9656、7817mg;术后12mo内2组血肌酐无显著性差异,以后对照组血肌酐水平上升较快,术后18mo～36mo,Dil组血肌酐水平明显低于对照组同期(P<0.05)。结论:肾移植术后长期应用Dil不仅可明显减少肾移植受者的CsA用量,而且可以改善移植肾功能。
Objective: To observe the effects of long-term use of calcium channel blocker (Dil) on CsA and renal function in renal transplant recipients. Methods: Dil was used to treat 67 renal transplant recipients who received CsA. 59 renal transplant recipients in the same period were used as control. The plasma concentration of CsA in two groups was adjusted within the therapeutic window. The amount of CsA in 36 months after treatment was observed. Changes in serum creatinine. Results: The amount of CsA in each group was 14353, 9656 and 7817 mg less than the control group on the 12th, 24th and 36th month after operation respectively. There was no significant difference in serum creatinine between the two groups within 12 months after operation, Postoperative 18mo ~ 36mo, Dil group serum creatinine levels were significantly lower than the control group (P <0.05). Conclusion: Long-term application of Dil after renal transplantation can not only significantly reduce CsA dosage in renal transplant recipients, but also improve graft function.