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目的观察 2型糖尿病患者深呼吸时RR间期E/I(expiration /inspiration ,每次呼气期最长RR间期均值除以每次吸气期最短RR间期的均值 )比值的改变 ,探讨心脏自主神经功能的非侵入性检查方法。方法 1 64例 2型糖尿病患者为观察组 ,1 4 2名健康人为对照组 ,记录每分钟 6次深呼吸时心电图 ,RR间期E/I比值。结果糖尿病 1 0年以上组 2 4例 ,RR间期E/I比值为 1 .0 5± 0 .0 9;5～ 1 0年组 2 8例 ,为 1 .0 7± 0 .0 6 ;与病程 5年以内组 1 1 2例 (1 .1 8± 0 .1 4 )、对照组 (1 .1 6± 0 .1 2 )比较 ,P均 <0 .0 1 .随病程延长 ,糖尿病RR间期E/I比值固定为 1的比例增高 ,1 0年以上 1 0 (1 0 / 2 4 )例 ,5～ 1 0年以上5(5/ 2 8)例 ,5年以下 8(8/ 1 1 2 )例 (P <0 .0 1 )。结论RR间期E/I比值可作为临床评价糖尿病心脏自主神经功能损害程度的参考指标
Objective To observe the change of the ratio of RR / expiration / inspiration (mean of the longest RR interval in each expiratory period divided by the mean of the shortest RR intervals in each inspiratory phase) during deep breathing in patients with type 2 diabetes mellitus Noninvasive examination of autonomic nerve function. Methods One hundred and sixty-four patients with type 2 diabetes mellitus were enrolled in the study. One hundred and two healthy individuals were control subjects. The electrocardiogram and RR interval E / I ratio of 6 deep breaths per minute were recorded. Results There were 24 cases of diabetes mellitus between 10 years and over. The E / I ratio of RR interval was 1.05 ± 0.99; 28 cases in 5 ~ 10 years group was 1.70 ± 0.60; Compared with the group of 112 cases (1.18 ± 0.14) and the control group (1.6 ± 0.12) within 5 years of course of disease, P <0.01.With the prolongation of duration, diabetes The ratio of the RR interval E / I ratio increased to 1, with 10 (10 of 24 cases) over 10 years, 5 (5/28) cases of 5 to 10 years, 8 / 1 1 2) cases (P <0 .0 1). Conclusion RR interval E / I ratio can be used as a clinical evaluation of diabetic cardiac autonomic nervous dysfunction reference index