论文部分内容阅读
O’Brien在《有毒磷酸酯类》一书中曾谈到:“几乎所有的有机磷毒剂都可在动物体内被降解,并且有时降解得相当迅速”,“动物在有机磷毒剂中毒后的死活很大程度上取决于体内激活酶和降解酶系统”。Edery等曾研究蟾蜍对有机磷毒剂的毒性,发现从淋巴囊注射DFP的LD卯值为1450mg/kg,而小鼠皮下DFP的LD_(50)值为4mg/kg,提出DFP主要是在血液中被解毒,并说明这两种动物血液的解毒能力差别悬殊。Zech等研究不同动物血清分解E600的能力,提出动物问这种能力的不同可能是引起毒性(LD_(50))差别的原因之一。Andersen等研究4种动物的脑乙酰胆碱酯酶(ACHE)与有机磷毒剂
O’Brien said in his book “Toxic Phosphates:” Almost all organophosphate poisons can be degraded in animals and sometimes degrade quite rapidly, “and” live and die after animals are poisoned by organophosphate poisons Much depends on the body activate enzyme and degradative enzyme system. " Edery et al. Studied the toxicity of toad to organophosphate poisons and found that the DML injected into the lymphatic sac was LD50 of 1450 mg / kg, whereas the LD 50 of the subcutaneous DFP was 4 mg / kg, suggesting that DFP is predominantly in the blood Be detoxified, and illustrate the vast difference in the detoxification capacity of the two animals’ blood. Zech et al. Studied the ability of different animal serum to decompose E600, suggesting that differences in the ability of animals to ask this may be responsible for the differences in toxicity (LD 50). Andersen et al. Studied four kinds of animal brain acetylcholinesterase (ACHE) and organic phosphate poisons