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肝硬化的某些临床特点:睾丸功能低下、免疫反应、维生素A和甲状腺激素代谢降低、蛋白合成减少、药物清除能力下降等均与缺锌有联系。本实验旨在用CCl_4诱发鼠产生肝硬化,从而研究锌对血氨和肝OTC活性所起的作用。材料和方法:按Proctor和Chatamra的方法,给重约200克的雄性大鼠10周四氯化碳使其产生肝硬化。实验动物分成三组,正常鼠(对照组)、肝硬化鼠、补锌肝硬化鼠(处理同四氯化碳诱发肝硬化组,另外饮水中补充醋酸锌)。
Some of the clinical features of cirrhosis: testicular dysfunction, immune response, reduced vitamin A and thyroid hormone metabolism, decreased protein synthesis, decreased drug scavenging, etc. are associated with zinc deficiency. The purpose of this experiment was to induce cirrhosis in mice induced by CCl_4 to study the effect of zinc on the activity of ammonia and hepatic OTC in blood. Materials and Methods: Male rats weighing about 200 grams were given cirrhosis with carbon tetrachloride for 10 weeks according to Proctor and Chatamra. The experimental animals were divided into three groups: normal rats (control group), cirrhotic rats, zinc-supplemented cirrhotic rats (treated with carbon tetrachloride-induced cirrhosis group and supplemented with zinc acetate in drinking water).