儿童患微小病变型肾病综合征(MCNS)最初对激素是敏感的,嗣后频繁复发是一个难题。已证明对频繁复发MCNS用激素仍然敏感,但常伴有严重激素毒性。用环磷酰胺或瘤可宁虽可带来长期缓解,但这些药物潜在的严重毒性作用亦不容忽视。对防止MCNS频繁复发至今尚未解决。试图去发现MCNS与组织学之间的关系,仅限于临床治疗成功的病例,而潜在性频繁复发的MCNS病例不能从组织学识别. Children suffering from minimal change nephrotic syndrome (MCNS) was initially hormone sensitive, frequent recurrence is a problem. It has been shown to be still sensitive to hormones that recurrent MCNS, but often accompanied by severe hormonal toxicity. With cyclophosphamide or tumor Ning can bring long-term relief, but the potential serious toxic effects of these drugs can not be ignored. To prevent frequent recurrence of MCNS has not yet been resolved. Attempts to discover the relationship between MCNS and histology were limited to cases of clinically successful treatment, and MCNS cases with potentially frequent recurrences could not be identified histologically.