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目的探讨联合应用神经节苷脂(GM1)和胞二磷胆碱(CDPC)治疗新生儿缺氧缺血性脑病的临床疗效。方法 58例中度缺氧缺血性脑病患儿随机被分为治疗组28例和对照组28例,治疗组联合应用神经节苷脂和胞二磷胆碱一周,观察组单独应用胞二磷胆碱作为对照,运用统计学原理对两组总有效率及神经系统主要症状消失时间进行分析研究,做出疗效评价。结果联合治疗组总有效率和神经系统主要症状消失时间均优于对照组,两者差异有显著意义(P<0.05)。结论联合应用GM1和CDPC较单一应用CDPC疗效更佳。
Objective To investigate the clinical effects of ganglioside GM1 and CDPC on neonatal hypoxic-ischemic encephalopathy. Methods Fifty-eight children with moderate hypoxic-ischemic encephalopathy were randomly divided into treatment group (n = 28) and control group (n = 28). The treatment group was treated with ganglioside and citicoline for one week. Choline as a control, the use of statistical principles of total effective rate of the two groups and the disappearance of the main symptoms of nervous system analysis and research to make the curative effect evaluation. Results The total effective rate and disappearance of the main symptoms of the nervous system in the combination therapy group were better than those in the control group, with significant difference (P <0.05). Conclusion The combination of GM1 and CDPC is better than single application of CDPC.