Roxithromycin(RU28965)是新研制的大环内酯类抗生素。体外抗菌谱同红霉素,但体内动态大有改善。口服150mg,约2小时可达最高血浓度6μg/ml,半衰期约7小时,向各组织移行良好,在上颌窦粘膜中可达0.3～3.7μg/ml的有效治疗浓度。作者在1987年11月～1988年2月治疗27例副鼻窦炎,其中急性15例,慢性急性发作者12例。饭前口服Roxithromycin150mg(1片),一日2次,连续7日。治疗期间不用其他药物,包括滴鼻剂。结果表明,它对急性副鼻窦炎及慢性副鼻窦炎急性发作的有效率分别为93.3%及91.7%,总有效率92.6%。细菌学检查,对 Roxithromycin (RU28965) is a newly developed macrolide antibiotic. Antibacterial spectrum in vitro with erythromycin, but much improved in vivo dynamics. Oral 150mg, about 2 hours up to a maximum blood concentration of 6μg / ml, half-life of about 7 hours to the organization of good migration in the maxillary sinus mucosa up to 0.3 ~ 3.7μg / ml effective therapeutic concentration. The authors treated 27 cases of paranasal sinusitis from November 1987 to February 1988, of which 15 were acute and 12 were acute exacerbations. Oral Roxithromycin 150mg (1 tablet), 2 times a day, for 7 days. No other medications, including nasal drops, were used during the treatment. The results show that its acute sinusitis and chronic sinusitis acute attack were 93.3% and 91.7%, respectively, the total effective rate was 92.6%. Bacteriological examination, right