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一、引言自Green和Arduini于1954年首先对海马的θ节律做了系统研究以来,这个课题在海马生理学的领域内一直占据着重要的地位。海马θ节律是在哺乳类动物海马中记录到的一种反映海马神经元同步化活动的电信号,其记录曲线近似正弦波,频率约4～7Hz。在制动的清醒动物,可通过施加各种自然的感觉刺激或伤害性刺激诱发;也可经给予拟胆碱药物而诱发;或动物处于一定的行为状态(包括异相睡眠)时自发。由于这种电活动的频率特征与人脑电图的θ节律是一致的,故最早的命名便称作海马θ节律。目前有人将之称为“节律性慢波
I. INTRODUCTION Since Green and Arduini first systematically studied the θ rhythm of the hippocampus in 1954, this subject has been playing an important role in the field of hippocampal physiology. The hippocampal θ rhythm is an electrical signal recorded in the mammalian hippocampus that reflects the synchronizing activity of the hippocampal neurons. The recording curve approximates a sine wave with a frequency of about 4 to 7 Hz. In braking a conscious animal, it can be induced by applying various natural sensory stimuli or nociceptive stimuli; it can also be induced by the administration of cholinergic drugs; or spontaneous when the animal is in a certain behavioral state (including out-of-phase sleep). Since the frequency characteristic of this electrical activity is consistent with the θ rhythm of EEG, the earliest nomenclature is called the θ rhythm of the hippocampus. At present, some people call it “rhythmic slow wave.”