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蛋白激酶C(PKC)是一类由多种同工酶组成的丝氨酸 /苏氨酸蛋白激酶家族。高血糖和游离脂肪酸 (FFA)可影响信号传导通路 ,特别是激活二酰甘油 (DG) PKC途径 ,PKC的激活可引起胰岛素抵抗 (IR)及糖尿病血管并发症。PKC β选择性抑制剂 (LY 3335 31)和维生素E对糖尿病血管并发症治疗方面已显示出良好的前景
Protein kinase C (PKC) is a family of serine / threonine protein kinases composed of multiple isozymes. Hyperglycemia and free fatty acids (FFA) can affect signaling pathways, especially the diacylglycerol (DG) PKC pathway, and activation of PKC can lead to insulin resistance (IR) and diabetic vascular complications. PKC β-selective inhibitors (LY 3335 31) and vitamin E have shown good promise in the treatment of diabetic vascular complications