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1959年7、8月间,我们应用呋喃西林治疗细菌性痢疾,获得很好效果,今将其治疗效果及与合霉素疗效对比作一分析报导。呋喃西林(FuraciIIinum)又名呋喃新(Nitrofurazone)为5—硝基—2呋喃甲醛缩脲,其化学结构式为:O_2N——CH=N—NH——NH_2呋喃西林是呋喃醛属中最佳之杀菌剂,对革兰氏阴性菌及阳性菌均有良好杀灭及抑制作用,主要为干扰细菌体内氧化酵素系统,使其混乱而无法生存。过去常作外用之杀菌消毒剂,苏联第七次全苏儿科医师表大会博士推荐了应用此药治疗小儿细菌性痢疾的效果,我们根据此报告应用于临床,用量每天每公斤体重10毫克,分4—6次内服,最初应用于重型痢疾患儿年龄均在12岁以下,有发热、精神不振、大便频数有痢疾改变者,共治疗21例,其疗效见表1。
July and August 1959, we applied nitrofurazone treatment of bacterial dysentery, and achieved good results, the treatment of this and compared with the efficacy of tetracycline for an analysis report. FuraciIIinum, also known as Nitrofurazone, is 5-nitro-2-furfural, its chemical structure is: O_2N - CH = N - NH - NH_2 Nitrofurazone is the best bactericide , Gram-negative bacteria and positive bacteria have a good kill and inhibitory effect, mainly to interfere with bacterial oxidase system, making it confused and unable to survive. In the past often used as external disinfection and disinfection agents, the Soviet Union, the seventh session of the General Pediatrician Table doctor recommended the application of this drug in children with bacterial dysentery effect, we report the clinical application, the amount of 10 mg per kilogram of body weight per day, 4-6 times orally, initially used in children with severe dysentery under the age of 12, have fever, lack of energy, dysentery frequency changes in those who have dysentery, a total of 21 cases of treatment, the efficacy of Table 1.