重度酒精性肝炎多发于酒精性肝硬化病人,死亡率高。激素疗法用于这类严重肝损伤病人可降低病死率。然而,需要借助肝活检才能确诊此类病人,有一定难度。因此,细胞外基质血清标志物被提出用于酒精性肝病的非侵人性诊断。本项研究的目的是确定五种细胞外基质血清标志物:层粘连蛋白、Ⅲ型胶原蛋白肽链N末端(PⅢNP)、Ⅰ型(CⅠ)、Ⅲ型(CⅢ)和Ⅳ型胶原在肝硬化及酒精性肝病中鉴别出严重组织学改变的酒精性肝炎的意义。 Severe alcoholic hepatitis occurs in patients with alcoholic liver cirrhosis, high mortality. Hormone therapy for such patients with severe liver injury can reduce mortality. However, the need for liver biopsy to confirm such patients, a certain degree of difficulty. Therefore, extracellular matrix serum markers have been proposed for the non-invasive diagnosis of alcoholic liver disease. The purpose of this study was to identify five extracellular matrix serum markers: laminin, type III collagen peptide N-terminal (PⅢNP), type Ⅰ (CⅠ), type Ⅲ (C Ⅲ) and type Ⅳ collagen in cirrhosis And alcoholic liver disease in the identification of severe histological changes of alcoholic hepatitis significance.