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目的探讨阿托伐他汀联合吡格列酮对2型糖尿病患者血脂水平及血管内皮功能的影响。方法选择治疗的54例2型糖尿病患者作为观察对象,随机分为观察组和对照组,各27例。对照组每晚服用阿托伐他汀治疗,观察组在对照组的基础上加用吡格列酮。比较两组患者治疗前后的血脂水平及血管内皮功能变化。结果与治疗前相比,两组治疗后TC、TG及LDL-C水平均明显降低,而HDL-C水平则升高,差异有统计学意义(P<0.05);两组治疗前后组间相比差异无统计学意义(P>0.05);治疗后观察组患者NO及FMD水平均高于对照组,差异有统计学意义(P<0.05);两组患者ET-1相比差异无统计学意义(P>0.05)。结论 2型糖尿病患者采用阿托伐他汀联合吡格列酮治疗,可有效促进血脂代谢,减少炎症反应,改善患者的血管内皮功能。
Objective To investigate the effects of atorvastatin combined with pioglitazone on blood lipid levels and endothelial function in type 2 diabetic patients. Methods Select 54 cases of type 2 diabetes mellitus as observation object, were randomly divided into observation group and control group, 27 cases each. The control group took atorvastatin every night, and the observation group was given pioglitazone on the basis of the control group. Blood lipid levels and endothelial function were compared between the two groups before and after treatment. Results Compared with those before treatment, the levels of TC, TG and LDL-C in both groups were significantly decreased, while the levels of HDL-C were significantly increased in both groups (P <0.05). Before and after treatment, (P> 0.05). After treatment, the levels of NO and FMD in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in ET-1 between the two groups Significance (P> 0.05). Conclusions Patients with type 2 diabetes treated with atorvastatin combined with pioglitazone can effectively promote blood lipid metabolism, reduce the inflammatory reaction and improve the vascular endothelial function in patients.