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目的:探讨新疆多民族人群内皮型一氧化氮合酶(eNOS)基因多态性与冠心病的相关性。方法:采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)方法,分别对新疆哈萨克族冠心病患者(87例)及健康对照组(70例);土尔扈特蒙古族冠心病患者(73例)及健康对照组(87例);汉族冠心病患者(79例)及健康对照组(91例);维吾尔族冠心病患者(84例)及健康对照组(82例)作eNOS基因G894T多态性检测。结果:4个民族冠心病组与健康对照组比较:汉族冠心病患者;土尔扈特蒙古族冠心病患者基因型及等位基因频率方面均无显著性差异P>0.05。哈萨克族、维吾尔族在基因型及等位基因频率两个方面均有著性差异P<0.05。结论:eNOS基因G894T多态性与汉族;土尔扈特蒙古族冠心病患者的关系不明显,与哈萨克族;维吾尔族冠心病有相关性。
Objective: To investigate the relationship between polymorphism of endothelial nitric oxide synthase (eNOS) gene and coronary heart disease in multi-ethnic population of Xinjiang. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the risk of coronary heart disease (87 cases) and healthy control group (70 cases) (73 cases) and healthy control group (87 cases); Han patients with coronary heart disease (79 cases) and healthy control group (91 cases); Uygur patients with coronary heart disease (84 cases) and healthy control group (82 cases) For eNOS gene G894T polymorphism detection. Results: There was no significant difference in genotypes and allele frequencies between Mongolian patients with coronary heart disease and coronary heart disease among Han nationalities in 4 ethnic coronary heart disease groups and healthy controls. Kazak, Uygur ethnic differences in genotypes and allele frequencies were significant (P <0.05). Conclusion: There is no significant relationship between G894T polymorphism of eNOS gene and Han nationality and Mongolian patients with coronary heart disease in Turgh Autonomous Region, but not with Kazak nationality and Uigur ethnic group.