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目的：分析胸腺肽（ＴＰ）对长期使用氢化可的松（ＨＣ）并致敏的小鼠免疫器官与免疫功能的影响。方法：１６只Ｃ５７ＢＬ小鼠随机分ＴＰ组、ＨＣ组与正常组。ＴＰ组与ＨＣ组小鼠肌肉注射ＨＣ０．５ｍｇ／ｄ２周，用Ｈｅｐ２细胞致敏。ＴＰ组腹腔注射（腹注）ＴＰ１０μｇ／ｄ，ＨＣ组腹注ＮＳ，共６ｄ。取胸腺和脾组织行光镜、电镜观察，测淋巴细胞毒试验、溶肿瘤细胞反应等指标。结果：ＴＰ能促ＨＣ致萎缩的胸腺、脾淋巴细胞增生，提高免疫活性细胞的细胞免疫及体液免疫功能。结论：ＴＰ能调整ＨＣ的免疫抑制作用，提高淋巴细胞免疫功能。
OBJECTIVE: To analyze the effect of thymosin (TP) on the immune organs and sensitization to long-term use of hydrocortisone (HC) in mice. Methods: Sixteen C57BL mice were randomly divided into TP group, HC group and normal group. TP group and HC group mice intramuscular injection HC0.5mg / d2 weeks, with Hep 2 cells sensitized. TP group intraperitoneal injection (abdominal) TP10μg / d, HC group abdominal injection of NS, a total of 6d. Take thymus and spleen tissue light microscope, electron microscopy, measured lymphocyte cytotoxicity test, tumor response and other indicators of tumor cells. Results: TP can promote HC-induced atrophy of thymus and spleen lymphocyte proliferation, and improve cellular immunity and humoral immunity of immunocompetent cells. Conclusion: TP can adjust the immunosuppressive effect of HC and improve the immune function of lymphocytes.