结缔组织疾病,特别是系统性红斑性狼疮,常常有神经精神症状。然而,硬皮病的原发性中枢神经系统损害很少见。作者报告一例42岁妇女,数年前因有雷诺氏现象、毛细血管扩张及典型的皮肤改变而诊断为硬皮病。两周前因出现幻觉而住院。患者面部、手及手指皮肤紧张,色素减退,胸前有毛细血管扩张,血压100/70毫米汞柱。神经系统检 Connective tissue diseases, especially systemic lupus erythematosus, often have neuropsychiatric symptoms. However, primary CNS damage to scleroderma is rare. The authors report a 42-year-old woman who was diagnosed with scleroderma several years ago because of Raynaud’s phenomenon, telangiectasia and typical skin changes. Hospitalized for hallucinations two weeks ago. Patients face, hands and fingers skin tension, hypopigmentation, chest dilated capillaries, blood pressure 100/70 mm Hg. Neurological examination