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目的:探索晚卵泡期孕酮(P)水平升高与体外受精(IVF)卵巢期胚胎移植异位妊娠风险的关系。方法:回顾性分析行IVF卵裂期胚胎移植或囊胚移植并获得妊娠的1 508个周期异位妊娠发生情况。根据hCG注射日P水平分为P正常组(P≤1.5 ng/ml)与P升高组(P>1.5 ng/ml),比较组间的异位妊娠发生率。结果:卵裂期胚胎移植P正常组、P升高组异位妊娠率分别为2.8%(32/1 132)和7.9%(11/140),差异有统计学意义(P=0.005)。囊胚移植P正常组、P升高组异位妊娠率分别为1.5%(3/199)和5.4%(2/37),组间差异无统计学意义(P>0.05)。结论:晚卵泡期P升高可增加IVF卵裂期胚胎移植异位妊娠风险。
Objective: To explore the relationship between the level of progesterone (P) in late follicles and the risk of ectopic pregnancy in IVF ovarian embryo transfer. Methods: A retrospective analysis of IVF cleavage embryo transfer or blastocyst transfer and pregnancy obtained 1 508 cycles of ectopic pregnancy. The levels of P were divided into P normal group (P≤1.5 ng / ml) and P elevated group (P> 1.5 ng / ml) on the day of hCG injection, and the incidence of ectopic pregnancy was compared between groups. Results: The rates of ectopic pregnancy in P normal group and P elevated group were 2.8% (32/1 132) and 7.9% (11/140) respectively, the difference was statistically significant (P = 0.005). The rate of ectopic pregnancy in P normal group and P elevated group was 1.5% (3/199) and 5.4% (2/37) respectively, there was no significant difference between the two groups (P> 0.05). Conclusions: Elevated follicular phase P may increase the risk of ectopic pregnancy in IVF cleavage embryo transfer.