Wnt信号通路是一条进化上保守的信号途径，其具有广泛生物学效应，可调控细胞的黏附、迁移、增殖以及凋亡。近年来，随着研究的深入， Wnt信号通路与呼吸系统疾病的关系被不断揭示，该文通过总结近年来关于Wnt信号通路的相关文献，探讨 Wnt信号通路与呼吸系统慢性疾病以及肺癌的关系，为进一步探索此类疾病的临床诊治提供资料。“,”The Wnt signaling pathway is an evolutionarily conserved signaling pathway .Wnt pathway is involved in a wide range of biological functions,such as cell adhesion,migration,proliferation and apoptosis. In recent years, with the deepening of the research, the relationship between Wnt signaling pathway and respiratory system diseases is revealed.Here is to explore the relationship between Wnt signaling pathway and chronic respiratory diseases and lung cancer through summarizing the latest articles,laying the foundation for further exploration of the clinical diagnosis and treatment.