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目的了解少数民族地区吸毒人群HIV感染的行为、CCR5受体基因变异因素。方法对广西西部某县戒毒所内的吸毒人员进行问卷调查,检测HIV血清抗体、受体基因CCR5△32/△32纯合子。结果HIV感染率为57.14%,静脉注射率为86%,共用注射器率为47.9%。80.4%和8.9%的吸毒人员分别曾有过异性和同性性行为。没有发现136-bp△32CCR5突变体。结论吸毒人群为HIV易感人群,静脉吸毒、性交为HIV感染的行为因素,应采取行为干预措施来预防控制HIV的传播。
Objective To understand the behavior of HIV infection and the gene mutation of CCR5 in drug addicts in ethnic minority areas. Methods A questionnaire survey was conducted among drug addicts in a county drug rehabilitation center in western Guangxi to detect HIV antibody CCR5 △ 32 / △ 32 homozygote. Results The rate of HIV infection was 57.14%, the rate of intravenous injection was 86%, and the rate of shared syringes was 47.9%. 80.4% and 8.9% of drug addicts had had heterosexual and homosexual activities respectively. No 136-bp? 32CCR5 mutant was found. Conclusion The drug addicts are HIV-susceptible, intravenous drug users and sexual intercourse are the behavioral factors of HIV infection. Behavior interventions should be taken to prevent and control the spread of HIV.