目的:探讨合并慢性肾脏病孕妇和子痫前期孕妇的n β2微球蛋白、血清免疫球蛋白，转铁蛋白和水平差异。n 方法:选取120例2018年6月至2019年6月期间桂东人民医院接收的孕妇，根据孕妇情况分为三组，即子痫前期(PE组)(50例)、肾脏病组(38例)和对照组(32例)，所有孕妇检测n β2微球蛋白、血清免疫球蛋白(immunoglobulin，Ig)(IgM、IgA、IgG)、转铁蛋白以及和sFlt-1和PLGF水平，计算sFlt-1/PLGF比值。n 结果:三组孕妇血清IgA水平无明显差异(n P>0.05)；PE组与肾脏病组IgG水平及IgM较对照组明显降低(n P值均<0.05)，其中肾脏病组较PE组明显降低(n P<0.05)；三组孕妇血清n β2微球蛋白水平比较存在明显差异，其中肾脏组孕妇较PE组及对照组明显升高(n P值均<0.05)；三组孕妇血清转铁蛋白水平比较也存在明显差异，肾脏病组较PE组、对照组明显降低(n P值均0.05)；三组血清sFlt-1、PLGF水平以及sFlt-1/PLGF比值存在明显差异(n P<0.05)，其中PE组血清sFlt-1与sFlt-1/PLGF比值较肾脏病组与对照组明显升高，而PLGF水平降低(n P0.05)；其24 h尿蛋白定量与转铁蛋白水平呈负相关(n r＝-0.441，n P<0.05)，与n β2微球蛋白水平呈正相关(n r＝0.556，n P<0.05)，与IgM、IgM呈负相关(n r＝-0.425、-0.418，n P值均<0.05)；其分娩孕周与转铁蛋白水平呈正相关(n r＝0.415，n P<0.05)，与n β2微球蛋白呈负相关(n r＝-0.433，n P<0.05)，与IgG、IgM无相关性(n r＝0.165，0.152，n P<0.05)；与血清sFlt-1及sFlt-1/PLGF比值呈正相关(n r＝0.665、0.796，n P值均<0.05)；与PLGF水平呈负相关(n r＝0.452，n P<0.05)；肾脏病组：孕妇血压与血清n β2微球蛋白呈相关(n r舒张压＝0.556，n r收缩压＝0.592，n P值均<0.05)，与转铁蛋白与IgM、IgG均无相关性(n r＝0.127、0.114、0.121，n P值均<0.05)；24 h尿蛋白定量与IgM呈负相关(n r＝-0.524，n P<0.05)，与n β2微球蛋白呈正相关(n r＝0.567，n P0.05)；分娩孕周与转铁蛋白呈正相关(n r＝0.417，n P<0.05)，与n β2微球蛋白水平呈负相关(n r＝0.573，n P<0.05)，与IgG、IgM无相关性(n r＝0.246，0.235，n P值均<0.05)；与血清sFlt-1及sFlt-1/PLGF比值呈负相关(n r＝0.458、0.689，n P值均<0.05)；与PLGF水平呈正相关(n r＝0.431，n P0.05); The levels of IgG and IgM in PE group and kidney disease group were significantly lower than those in control group(n P<0.05), while those in renal disease group were significantly lower than those in PE group(n P<0.05); There was significant difference in serumn β2-microglobulin levels among the three groups(n P<0.05), and the level of serumn β2-microglobulin in renal group was significantly higher than that in PE group and control group(n P<0.05); The level of serum transferrin in the three groups was also significantly different(n P<0.05). The level of serum transferrin in renal disease group was significantly lower than that in PE group and control group(n P0.05); The levels of sFlt-1, PLGF and the ratio of sFlt-1/PlGF were significantly different among the three groups(n P<0.05). The ratio of sFlt-1 and sFlt-1/PlGF in PE group was significantly higher than that in kidney disease group and control group, and PlGF level was decreased(n P0.05); The 24 h urinary protein was negatively correlated with transferrin( n r=-0.441, n P<0.05), positively correlated with microglobulin(n r=0.556, n P<0.05), and negatively correlated with IgM and IgM(n r=-0.425, -0.418, all n P values <0.05); The gestational weeks of delivery were positively correlated with transferrin( n r=0.415, n P<0.05), negatively correlated withn β2-microglobulin(n r=-0.433, n P<0.05), but not with IgG and IgM(n r=0.165, 0.152, all n P values <0.05); Serum sFlt-1 and sFlt-1/PlGF ratio were positively correlated( n r=0.665, 0.796, both n P values <0.05); In kidney disease group, blood pressure was correlated with serum n β2-microglobulin(n rdiastolic blood pressure=0.556, n rsystolic blood pressure=0.592, n P<0.05), but not with transferrin, IgM and IgG(n r=0.127, 0.114, 0.121, all n P values <0.05); 24 h urine protein was negatively correlated with IgM( n r=-0.524, n P<0.05), and positively correlated withn β2-microglobulin(n r=0.567, n P0.05); The gestational weeks of delivery were positively correlated with transferrin(n r=0.417, n P<0.05), negatively correlated withn β2-microglobulin(n r=0.573, n P<0.05), but not with IgG and IgM(n r=0.246, 0.235, both n P values <0.05). Serum sFlt-1 and sFlt-1/PlGF ratio were negatively correlated( n r=0.458, 0.689, both n P values <0.05); There was a positive correlation between PlGF and PlGF( n r=0.431, n P<0.05).n Conclusion:The levels of transferrin, n β2-microglobulin, IgM, IgG, sFlt-1 and PLGF are significantly different between PE and pregnant women with chronic kidney, especially the ratio of sFlt-1 to PLGF may provide a basis for their differential diagnosis of PE and chronic kidney.n