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Various chemical modifications at the nucleosome, including DNA methylation, histone H3 acetylation (H3Ac), and histone H3 mono-/di-/trimethylation at various lysine residues (H3K4me3, H3K9me1/me2, H3K27me3, and H3K36me2/me3), underlie the delicate control of chromatin architecture (Ramirez-Prado et al. 2018). These modifications influence gene ex-pression by changing the accessibility of chromatin by RNA Pol Ⅱ and chromatin-binding proteins, under-pinning the importance of chromatin landscape in gene regulation (Malapeira et al. 2012).