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目的:观察Toll样受体4(TLR4)在口腔鳞状细胞癌(OSCC)组织中的表达和分布,分析其与OSCC临床特征之间的关系。方法:选取OSCC组织55例作为实验组,10例正常口腔黏膜作为对照组,应用免疫组织化学Envision两步法检测组织中TLR4的表达和分布情况。结果:TLR4在正常口腔黏膜组织呈现微弱表达或不表达,而在OSCC组织中表达明显增强;TLR4的阳性表达与患者性别、年龄、肿瘤的局部侵袭性无明显相关性(P>0.05),而与肿瘤的Border病理分级、区域或远处淋巴结转移有关(P<0.05)。结论:在OSCC组织中TLR4的表达量明显高于正常口腔黏膜,提示TLR4可能参与OSCC的发生和发展过程,并与肿瘤的生物学特征相关。
Objective: To observe the expression and distribution of Toll-like receptor 4 (TLR4) in oral squamous cell carcinoma (OSCC) and to analyze its relationship with the clinical features of OSCC. Methods: 55 cases of OSCC tissue were selected as experimental group and 10 cases of normal oral mucosa as control group. The expression and distribution of TLR4 in tissues were detected by immunohistochemistry Envision two-step method. Results: The expression of TLR4 in normal oral mucosa showed weak or no expression, but significantly increased in OSCC. The positive expression of TLR4 had no significant correlation with the gender, age and local invasion of tumor (P> 0.05) It was associated with tumor border classification and regional or distant lymph node metastasis (P <0.05). Conclusion: The expression of TLR4 in OSCC tissues is significantly higher than that in normal oral mucosa, suggesting that TLR4 may be involved in the pathogenesis and development of OSCC and related to the biological characteristics of the tumor.